Since demonstrating reduction in undiagnosed TB in Zimbabwe, leading to WHO policy change in 2013, Liz Corbett (WT Senior Fellow) introduced spatial and enhanced TB recording in Blantyre. Our 2011-16 database of >12,000 TB cases confirms population-level impact from active case-finding, suggesting lasting behaviour change as a key mechanism, and quantitative support for an emerging theme of marginalisation of male needs.
In the lab, we have described incomplete restoration of anti-TB immunity in HIV-infected patients on ART, supporting need for prolonged preventive therapy for HIV patients.
(PIs: Corbett, MacPherson)