MLW has a 25 year history of world-class severe malaria research which has helped to define those at greatest risk of death, improved our understanding of severe disease and patho-physiology, including the importance of retin-opathy and improved outcomes in patients with cerebral malaria. Work on the Paediatric Research Ward (PRW) has identified increased brain volume as a major contributor to death in children with stringently defined cerebral malaria imaged with MRI; 37% of retinopathy-positive children with CM and in-creased brain volume do not survive.
(PIs: Taylor, Mwapasa, Terlouw)