In work spanning 20 years, MLW has completed several landmark studies of rotavirus gastroenteritis. These include the most comprehensive clinical description of rotavirus and HIV infec-tion ever undertaken; the first clinical trial of a modern rotavirus vaccine in Africa leading to a global vaccine recommendation; and the first description from a low income country of real-world impact of routine rotavirus vac-cination including ~ 40% reduction in child deaths due to diarrhoea (unpublished]. The biological basis of reduced vaccine perfor-mance compared with high income countries is currently being explored.
(PIs: Bar-Zeev, Cunliffe)